Body Swelling Overview
Methergine methylergonovine maleate acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude Grapefruit Thrombophlebitis rhythmic contractions. Thus, it induces a rapid and sustained tetanic uterotonic effect Grapefruit Thrombophlebitis shortens the third stage of labor and reduces blood loss. The onset of action after I, Grapefruit Thrombophlebitis. Pharmacokinetic studies following an I.
Ergot alkaloids are mostly eliminated by hepatic metabolism and excretion, and the decrease in Grapefruit Thrombophlebitis following oral administration is probably a result of first-pass metabolism in the liver, Grapefruit Thrombophlebitis. Bioavailability studies conducted in fasting healthy female volunteers have shown that oral absorption of a 0, Grapefruit Thrombophlebitis.
The extent of absorption of the tablet, based upon methylergonovine plasma concentrations, was found to be equivalent to that of the I. The plasma level decline was biphasic with a mean elimination half-life of 3. A delayed gastrointestinal absorption T max about 3 hours of Methergine tablet might be observed in postpartum women during continuous treatment with this oxytocic agent.
Following delivery of placenta, for routine management of uterine atony, Grapefruit Thrombophlebitis and subinvolution of the uterus. For control of uterine hemorrhage in the second stage of labor following delivery of the anterior shoulder, Grapefruit Thrombophlebitis. This drug should not be administered I. V administration is considered essential Grapefruit Thrombophlebitis a lifesaving measure, Methergine methylergonovine maleate should be given slowly over a period of no less than 60 seconds with careful monitoring of blood pressure.
Intra-arterial or periarterial injection should be strictly avoided, Grapefruit Thrombophlebitis. Mothers should not breast-feed during treatment with Methergine, Grapefruit Thrombophlebitis. Milk secreted during this period should be discarded.
Methergine may produce adverse effects in the breast-feeding Grapefruit Thrombophlebitis. Methergine may also reduce the yield of breast milk.
Mothers should wait at least 12 hours after administration of the last dose of Methergine before initiating or resuming breast feeding. Patients with coronary artery disease or risk factors for coronary artery disease e. Inadvertent administration of Methergine to newborn infants has been reported.
In these cases of inadvertent neonatal exposure, symptoms such as respiratory depression, convulsions, cyanosis and oliguria have been reported. Usual treatment is symptomatic. However, in severe cases, respiratory and cardiovascular support is required. Methergine has been administered instead of vitamin K and Hepatitis B vaccine, medications which are routinely administered to the newborn.
Due to the potential for accidental neonatal exposure, Methergine injection should be stored separately from medications intended for neonatal administration. Caution should be exercised in the presence of sepsis, obliterative vascular disease.
Also use with caution during the second stage of labor. The necessity for manual removal of a retained placenta should occur only rarely with proper technique and adequate allowance of time for its spontaneous separation. CYP 3A4 inhibitors Grapefruit Thrombophlebitis. There have been rare reports of serious adverse events Grapefruit Thrombophlebitis connection with the coadministration of certain ergot alkaloid drugs e. Although there have been no reports of such interactions with methylergonovine alone, potent CYP 3A4 inhibitors should not be coadministered with methylergonovine.
Examples of some of the more potent CYP 3A4 inhibitors include macrolide antibiotics e. Less potent CYP 3A4 inhibitors should be administered with caution, Grapefruit Thrombophlebitis.
Less potent inhibitors include saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, and clotrimazole.
These lists are not exhaustive, and the prescriber should consider the effects on CYP 3A4 of other agents being considered for concomitant use with methylergonovine.
Caution should be exercised when Methergine is used concurrently with beta-blockers. Concomitant administration with beta-blockers may enhance the vasoconstrictive action of ergot alkaloids. Methylergonovine maleate produces vasoconstriction and can be expected to reduce the effect of glyceryl trinitrate and other antianginal drugs, Grapefruit Thrombophlebitis. Caution should be exercised when Methergine methylergonovine maleate is used concurrently with other vasoconstrictors, ergot alkaloids, or prostaglandins.
No long-term studies have been performed in animals to evaluate Grapefruit Thrombophlebitis potential. The effect of the drug on mutagenesis or fertility has not been determined. Animal reproductive studies have not been conducted with Methergine. It is also not known whether methylergonovine maleate can cause fetal harm or can affect reproductive capacity.
Use of Methergine is contraindicated during pregnancy because of its uterotonic effects. The uterotonic effect of Methergine is utilized after delivery to assist involution and decrease hemorrhage, shortening the third stage of labor. Mothers should not breast-feed during treatment with Methergine and at least 12 hours after administration of the Grapefruit Thrombophlebitis dose.
Safety and effectiveness in pediatric patients have not been established. Clinical studies of Methergine did not include sufficient number of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in response between the elderly and younger patients.
In general dose selection for an elderly patient should be cautious, Grapefruit Thrombophlebitis, usually starting at the low end of the dosing range, Grapefruit Thrombophlebitis, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Hypotension has also been reported. Abdominal Grapefruit Thrombophlebitis caused by uterine contractionsnausea and vomiting have occurred occasionally. Rarely observed reactions have included: There have been rare isolated reports of anaphylaxis, without a proven causal relationship to the drug product.
The following adverse drug reactions have been derived from post-marketing experience with Methergine via spontaneous case reports. Because these reactions are reported voluntarily from a population of uncertain size, it Grapefruit Thrombophlebitis not possible to reliably estimate their frequency which is therefore categorized as not known. Methergine methylergonovine maleate has not been associated with drug abuse or dependence of either a physical or psychological nature, Grapefruit Thrombophlebitis.
Symptoms of acute overdose may include: Because reports of overdosage with Methergine methylergonovine maleate are infrequent, the lethal dose in humans has not been established. Several cases of accidental Methergine injection in newborn infants have been reported, Grapefruit Thrombophlebitis, and in such cases 0.
However, recovery occurred in all but one case following a period of respiratory depression, hypothermia, hypertonicity with jerking movements, and convulsions.
Also, Grapefruit Thrombophlebitis, several children years of age have accidentally ingested up to 10 tablets 2 mg with no apparent ill effects. A postpartum patient took 4 tablets at one time in error and reported paresthesias and clamminess as her only symptoms, Grapefruit Thrombophlebitis. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, Grapefruit Thrombophlebitis.
May be repeated as required, at intervals of hours, Grapefruit Thrombophlebitis. White, round, biconvex Grapefruit Thrombophlebitis tablets debossed with "n" on one side and "01" on the other side.
Available in bottles of 7, 12, 28 and tablets. Postpartum Bleeding misoprostoloxytocinCytotecPitocinGrapefruit ThrombophlebitisGrapefruit Thrombophlebitis, carboprostSyntocinonmethylergonovineMore The easiest way to lookup drug information, Grapefruit Thrombophlebitis, identify pills, Grapefruit Thrombophlebitis, check interactions and set up your own personal medication records.
Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. This material is provided for educational purposes only and is not intended Grapefruit Thrombophlebitis medical advice, diagnosis or treatment. To view content sources and attributions, please refer to our editorial policy. We comply with the HONcode standard for trustworthy health information - verify here. Skip to Content googletag, Grapefruit Thrombophlebitis.
Overview Side Effects Dosage More. Methylergonovine maleate, USP, 0. Its structural formula is: Print this page Add to My Med List. Methergine Rating 7 User Reviews 8.
bumetanide, Bumex (discontinued brand): Drug Facts, Side Effects and Dosing
Swelling is an increase in the size or a change in the shape of an area of the body. Swelling can be caused by collection of body fluid, tissue growth, or abnormal movement or position of tissue, Grapefruit Thrombophlebitis. Most people will have swelling at some time.
When it is hot and you have stood or sat in the same position for a long time, you might notice swelling in your feet and ankles. Staying Joghurt von Krampfadern one position for any length of time increases the risk that the lower legs, feet, Grapefruit Thrombophlebitis, or hands will swell because body fluid will normally move down a limb from the effects of gravity.
Swelling can also be caused by heat-related problems, such as heat edema from working or being Grapefruit Thrombophlebitis in a hot environment, Grapefruit Thrombophlebitis. Body fluid can collect in different tissue spaces of the body localized or can affect the whole body generalized.
Causes of localized swelling include:. Some people may experience swelling as a reaction to a medical treatment, procedureor surgery. Swelling from Grapefruit Thrombophlebitis medical treatment may be related to the procedure or to a substance, such as dye, used during the procedure. Swelling may occur at an intravenous IV site used during a procedure or at an IV site used for medicines given at home, Grapefruit Thrombophlebitis.
Some swelling at the site of surgery is normal, such as swelling of the arm after a mastectomy. Lymphedema is swelling that occurs in an area around lymph nodes that have Grapefruit Thrombophlebitis removed such as following surgery or injured such as following radiation treatments. Swelling can also be caused by the fluctuation of hormone levels within the body.
Some women may notice swelling from retaining fluid during their menstrual cycles, Grapefruit Thrombophlebitis. This may be called cyclical edema because it is related to the menstrual cycle, Grapefruit Thrombophlebitis. Some women experience mild swelling in their hands or feet during pregnancy. Grapefruit Thrombophlebitis in the feet may be more noticeable in the third trimester of the pregnancy. Generalized swelling can be a sign of a pregnancy-related problem called preeclampsia.
For more information, see the topic Pregnancy-Related Problems. Swelling can occur when tissues move out Grapefruit Thrombophlebitis their normal position, Grapefruit Thrombophlebitis, such as hernias in the abdomen.
For more information, see the topic Inguinal Hernia, Grapefruit Thrombophlebitis. Most of the time swelling is mild and goes away on Grapefruit Thrombophlebitis own. You may not even know what caused the swelling. Home treatment Bolotov Varizen usually all that is needed to relieve mild symptoms.
Check your symptoms to decide if and when you should see a doctor. Causes of localized swelling Grapefruit Thrombophlebitis Injury to a specific body area. Bruising hematoma from an injury is Grapefruit Thrombophlebitis by tears Grapefruit Thrombophlebitis the small blood vessels under the skin.
Bleeding can also affect the joint hemarthrosis or the area that cushions and lubricates the joint traumatic bursitis. Swelling can affect just one area or may involve large sections of the body, such as swelling that occurs following a motor vehicle accident, Grapefruit Thrombophlebitis. Infection, which can occur in a joint or under the skin. An abscess is a pocket of pus that forms at the site of infected tissue. Cellulitis is a skin infection that can cause mild or severe swelling.
Burnswhich can cause swelling at Grapefruit Thrombophlebitis site of the burn or in a larger area around the burn. Inflammation that occurs when tissue is irritated by overuse or repeated motion. Swelling of the tendon and swelling caused by a series of small tears around a tendon tendinosis can occur together or separately. Swelling of the sac that cushions and lubricates the joint bursitis can be caused by prolonged or repeated pressure or by activities that require repeated twisting or rapid joint movements.
Insect bites or stings. Most insect bites or stings cause a small amount of redness or swelling. Some people have an allergic reaction to a bite or sting and develop a lot of swelling, redness, and itching.
Other causes, such as swelling related to a sac-shaped structure with clear fluid, bloodor pus cyst or a swollen gland Grapefruit Thrombophlebitis, such as a salivary gland.
Continued Causes of generalized swelling include: Sudden swelling of the hands and face may be a severe allergic reaction anaphylaxis and needs immediate medical evaluation. Autoimmune diseasessuch as lupusrheumatoid arthritisand scleroderma. These diseases can cause swelling when the body produces antibodies and other cells that attack and destroy tissues in the body.
Some medicines change how body fluids circulate, causing swelling. Swelling may also occur as an allergic reaction to a medicine. Circulation problems related to certain medical conditions, such as peripheral arterial diseaseGrapefruit Thrombophlebitis, heart failurediabetesor kidney disease. Grapefruit Thrombophlebitis causes swelling of an extremity when a blood clot interrupts blood flow in a vein in the arm or leg. Fluid that accumulates in the abdomen ascites because of other problems, Grapefruit Thrombophlebitis, such as malnutrition, Grapefruit Thrombophlebitis, cirrhosisor liver disease.
Continued Most of the time swelling is mild and goes away on its own. Understand Immunotherapy Painful Knees?
Clarifies the medications triamterene and hydrochlorothiazide (Maxzide, Dyazide), a diuretic prescribed to treat high blood pressure and edema. Read more about the.
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Bumetanide, Bumex (discontinued brand) loop diuretic medication information on side effects, dosage, and drug interactions.
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Progesterone (Prometrium) is used to treat overgrowth of the lining of the uterus and amenorrhea, a lack of menstrual periods.
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Methergine official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
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Methergine official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.