Indocin (Indomethacin): Side Effects, Interactions, Warning, Dosage & Uses Thrombophlebitis NSAIDs
It has the following structure:. Nabumetone is a white to off-white crystalline substance with a molecular weight of It is nonacidic and practically insoluble in water, but soluble in alcohol and most organic solvents. It has an n-octanol: Tablets for Oral Administration: Each oval-shaped, film-coated tablet contains mg or mg of nabumetone. Inactive ingredients consist of hypromellose, microcrystalline cellulose, Thrombophlebitis NSAIDs, polyethylene glycol, polysorbate 80, Thrombophlebitis NSAIDs, sodium lauryl sulfate, sodium starch glycolate, and titanium dioxide, Thrombophlebitis NSAIDs.
The mg tablets also contain iron oxides. Get emergency medical help if you have any of these signs of an Thrombophlebitis NSAIDs reaction: Stop taking nabumetone and seek medical attention or call your doctor at once if you have any of these serious side effects:. After observing the response to initial therapy with RELAFEN nabumetonethe dose and frequency should be adjusted to suit an individual patient's needs.
Osteoarthritis and Rheumatoid Arthritis: The recommended starting Thrombophlebitis NSAIDs is 1, mg taken as a single dose with or without food. Some patients may obtain more symptomatic relief from 1, mg to 2, mg per day. Dosages greater than 2, mg per day have not been studied. Patients weighing under 50 kg may be less likely to require dosages beyond 1, mg; therefore, Thrombophlebitis NSAIDs, after observing the response to initial therapy, the dose should be adjusted to meet individual patients' requirements.
NDC mg 's: Adverse reaction information was derived from blinded-controlled and open-labelled clinical trials and from worldwide marketing experience. Of the 1, patients who Thrombophlebitis NSAIDs RELAFEN nabumetone during US clinical trials, 1, were treated for at least 1 month, 1, Thrombophlebitis NSAIDs, for at least 3 months, for at least a year, Thrombophlebitis NSAIDs, and for at least 2 years.
More than patients have been treated for 5 years or longer. The most frequently reported adverse reactions were related to the gastrointestinal tract and included diarrheadyspepsiaand abdominal pain.
Anorexiajaundiceduodenal ulcerdysphagiaThrombophlebitis NSAIDs, gastric ulcergastroenteritisgastrointestinal bleeding, increased appetite, liver function Thrombophlebitis NSAIDs, melenahepatic failure. Astheniaagitation, anxietyconfusion, depressionmalaiseparesthesiatremorvertigo. Bullous eruptions, photosensitivityurticariapseudoporphyria cutanea tarda, toxic epidermal necrolysis, Thrombophlebitis NSAIDs, erythema multiformeStevens-Johnson syndrome.
Dyspneaeosinophilic pneumoniahypersensitivity pneumonitis, idiopathic interstitial pneumonitis. Albuminuriaazotemiahyperuricemiainterstitial nephritisnephrotic syndrome, vaginal bleeding, renal failure. Anaphylactoid reaction, anaphylaxisangioneurotic edema. Bilirubinuria, duodenitis Thrombophlebitis NSAIDs, eructationgallstonesgingivitisglossitispancreatitisrectal bleeding.
Anginaarrhythmiahypertensionmyocardial infarctionpalpitationssyncopethrombophlebitis. Dysuriahematuriaimpotencerenal stones. Body as a Whole: AnemiaThrombophlebitis NSAIDs, leukopeniagranulocytopenia.
HyperglycemiaThrombophlebitis NSAIDs, hypokalemiaweight loss. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of nabumetone and aspirin is not generally recommended Thrombophlebitis NSAIDs of the potential of increased adverse effects. Clinical studies, as well as post marketing observations, have shown that RELAFEN nabumetone can reduce the natriuretic effect of furosemide and thiazides in some patients.
This response has been attributed to inhibition of renal prostaglandin synthesis. NSAIDs have produced an Thrombophlebitis NSAIDs of plasma lithium levels and a reduction in renal lithium clearance. Thus, when NSAIDs and lithium are administered concurrently, Thrombophlebitis NSAIDs, subjects should be observed carefully for signs of lithium toxicity. NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices.
This may indicate that they could enhance the toxicity of methotrexate. Thrombophlebitis NSAIDs effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone. In vitro studies have shown that, because of its affinity for protein, 6MNA may displace other protein-bound drugs from their binding site.
Concomitant administration of an aluminum-containing antacid had no significant effect on the bioavailability of 6MNA. Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular CV thrombotic events, myocardial infarctionand stroke, which can be fatal. Patients with known CV disease or risk factors for CV disease may be at greater risk. To minimize the potential risk for an adverse CV event in patients treated with an NSAIDthe lowest effective dose should be used for the shortest duration possible.
Physicians and patients should remain alert for the development of such events, even in the absence of previous CV symptoms. There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use.
Patients taking thiazides or loop diuretics may have impaired response to these therapies when taking NSAIDs. Congestive Heart Failure and Edema: These serious adverse events can occur at any time, Thrombophlebitis NSAIDs, with or without warning symptoms, in patients treated with NSAIDs. These trends continue with longer duration of use, increasing the likelihood of developing a serious GI event at some time during the course of therapy.
However, even short-term therapy is not without risk. In controlled clinical trials involving 1, patients treated with RELAFEN nabumetone 1, followed for 1 year and for 2 years Thrombophlebitis NSAIDs, the cumulative Thrombophlebitis NSAIDs of peptic ulcers was 0. In patients with active peptic ulcer Krampfadern Strumpfhosen von Trägern, physicians must weigh the benefits of therapy with RELAFEN nabumetone against possible hazards, institute an appropriate ulcer treatment regimen and monitor the patients' progress carefully.
NSAIDs should be prescribed with extreme caution in those with a prior history of ulcer disease or gastrointestinal bleeding. Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, Thrombophlebitis NSAIDs, smoking, use of alcohololder age, and poor general health status.
Most spontaneous reports of fatal GI events are in elderly or debilitated patients and therefore, special care should be taken in treating this Thrombophlebitis NSAIDs. To minimize Thrombophlebitis NSAIDs potential risk for an adverse GI event in patients treated with an NSAID, the lowest effective dose should be used for the shortest possible duration.
Patients and physicians should remain alert for signs and symptoms of GI ulceration and bleeding Thrombophlebitis NSAIDs NSAID therapy and promptly initiate additional evaluation and treatment if a serious GI adverse event is suspected. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of an NSAID results in a dose-dependent decrease in prostaglandin synthesis and, secondarily, in a reduction of renal blood flow, which may precipitate overt renal decompensation.
Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunctionthose taking diuretics, and the elderly. No information is available from controlled clinical studies regarding the use of RELAFEN nabumetone in patients with advanced renal disease. The oxidized and conjugated metabolites of 6MNA are eliminated primarily by the kidneys. Emergency help should be sought in cases where an anaphylactoid reaction occurs.
These serious events may occur without warning. Patients should be informed about the signs and symptoms of serious skin manifestations and use of the drug should be discontinued at the first appearance of skin rash or Ekzem auf den Beinen Thrombophlebitis Thrombophlebitis NSAIDs sign of hypersensitivity.
Abrupt discontinuation of corticosteroids may lead to disease exacerbation. Patients on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue corticosteroids. The pharmacological activity of RELAFEN nabumetone in reducing fever and inflammation may diminish the utility of these diagnostic signs in detecting complications of presumed noninfectious, painful conditions. These laboratory abnormalities may progress, may remain unchanged, or Thrombophlebitis NSAIDs be transient with continuing therapy, Thrombophlebitis NSAIDs.
In addition, rare cases of severe hepatic reactions, including jaundice and fatal fulminant hepatitisliver necrosis and hepatic failure, some of them with fatal outcomes have been reported. If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur e. This may be due to fluid retention, occult or gross GI blood loss, or an incompletely described effect upon erythropoiesis. NSAIDs inhibit platelet aggregation and have been shown to prolong bleeding time in some patients.
Unlike aspirin, their effect on platelet function is quantitatively less, of shorter duration, and reversible. Patients with asthma may have aspirin-sensitive asthma. The use of aspirin in patients with aspirin-sensitive asthma has been associated with severe bronchospasm which can be fatal. Since Thrombophlebitis NSAIDs reactivity, including bronchospasm, between Thrombophlebitis NSAIDs and other non-steroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, RELAFEN nabumetone should not be administered to Thrombophlebitis NSAIDs with this form of aspirin sensitivity and should be used Thrombophlebitis NSAIDs caution in patients with preexisting asthma.
Based on Thrombophlebitis NSAIDs U. Patients should be informed of the following information before initiating therapy with an NSAID and periodically during the course of ongoing therapy, Thrombophlebitis NSAIDs. If clinical signs and symptoms consistent with liver or renal disease develop, systemic manifestations occur e.
In 2-year studies conducted in mice and rats, nabumetone had no statistically significant tumorigenic effect. Reproductive studies conducted in rats and rabbits have not demonstrated evidence of developmental abnormalities. However, animal reproduction studies are not always predictive of human response.
There are no adequate, well-controlled studies in pregnant women. RELAFEN nabumetone should be used in pregnancy only if the potential Thrombophlebitis NSAIDs justifies the potential risk to the fetus. Because of the known effects of non-steroidal anti-inflammatory drugs on the fetal cardiovascular system closure of ductus arteriosususe during pregnancy particularly late pregnancy should be avoided.
In rat studies with NSAIDs, as with other drugs known to inhibit prostaglandin synthesis, an increased incidence of dystociadelayed parturitionand decreased pup survival occurred.
It is not known whether this drug is excreted in human milk, however 6MNA is excreted in the milk of lactating rats. Because many drugs are Thrombophlebitis NSAIDs in human milk and Thrombophlebitis NSAIDs of the potential for serious adverse reactions in nursing infants from RELAFEN nabumetonea decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Safety and effectiveness in pediatric patients have not been established. No overall differences in Thrombophlebitis NSAIDs or safety were observed between these older patients and younger ones. Symptoms following acute NSAIDs overdoses are usually limited to lethargy, drowsiness, nausea, Thrombophlebitis NSAIDs, vomiting, and epigastric pain, which are generally reversible with supportive care.
Gastrointestinal bleeding can occur. Hypertension, acute renal failurerespiratory depressionand coma may occur, but are rare. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose.
There are no specific antidotes, Thrombophlebitis NSAIDs.
Should Topical NSAIDs Have Strict Heart Risk Warnings? Thrombophlebitis NSAIDs
Thrombophlebitis is Thrombophlebitis NSAIDs swollen or inflamed vein due to a blood clot. Superficial refers to veins just below the skin's surface. This condition may occur after injury to Thrombophlebitis NSAIDs vein.
Or it may occur after having medicines given into your veins. If you have a high risk for blood clots, you may develop them for no apparent reason. Your health care provider will diagnose this condition based mainly on the appearance of the affected area. Frequent checks of the pulseblood pressure, temperature, skin condition, and blood flow may be needed. If there are signs of an infection, Thrombophlebitis NSAIDs, skin or blood cultures may be done.
If you have a catheter or IV line, it will likely be removed if it is the cause of the thrombophlebitis. If clots in the deeper veins are also present, your provider may prescribe medicines to thin your blood. These medicines are called anticoagulants. Antibiotics are prescribed if you have an infection. Surgical removal phlebectomystrippingor sclerotherapy of the affected vein may be needed. These treat large varicose veins or to prevent thrombophlebitis in therapeutische Massage Krampfadern people.
This is often a Thrombophlebitis NSAIDs condition that does not cause complications. Symptoms often go away in 1 to 2 weeks. Hardness of the vein may remain for much longer. Also call if you already have the condition and your symptoms worsen or do not get better with treatment. When possible, avoid keeping your legs and arms still for long periods.
Move your legs often or take a stroll during long plane trips or car trips. Try to avoid sitting or lying down for long periods without getting up and moving about. Goldman L, Schafer AI, Thrombophlebitis NSAIDs, eds. Review provided by VeriMed Healthcare Network.
Risks for thrombophlebitis include: Cancer or liver disease Deep vein thrombosis Disorders that involve increased blood clotting may be inherited Infection Pregnancy Sitting or staying still for a prolonged period Use of birth control pills Swollen, twisted, and enlarged veins varicose veins. Symptoms may include any of the following: Skin redness, inflammation, tenderness, Thrombophlebitis NSAIDs, or pain along a vein just below the skin Warmth of the area Limb pain Hardening of the vein.
To reduce discomfort and swelling, your provider may recommend that you: Wear support stockingsif your leg is affected. Keep the affected leg Thrombophlebitis NSAIDs arm raised above heart level. Apply a warm compress to the area. Possible problems may include the following: Infections cellulitis Deep vein thrombosis. When to Contact a Medical Professional. Call for an appointment with your provider if you Thrombophlebitis NSAIDs symptoms of this condition.
In the hospital, swollen or inflamed veins can be prevented by: The nurse regularly changing the location of your IV line and Thrombophlebitis NSAIDs it if swelling, Thrombophlebitis NSAIDs, redness, or pain develop Walking and staying active as soon as possible after surgery or during a long-term illness When possible, avoid keeping your legs and arms still for long periods, Thrombophlebitis NSAIDs.
Superficial thrombophlebitis Superficial thrombophlebitis. Blood Clots Read more, Thrombophlebitis NSAIDs. Latest Health News Read more. Health Topics A-Z Read more, Thrombophlebitis NSAIDs.
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