Thrombophlebitis Blutungskomplikationen
Thrombophlebitis Blutungskomplikationen

Thrombozytopathie und Blutungskomplikationen bei Urämie

Thrombophlebitis Blutungskomplikationen

Thrombophlebitis Blutungskomplikationen Thrombophlebitis Blutungskomplikationen Sex Differences in Major Bleeding With Glycoprotein IIb/IIIa Inhibitors | Circulation


News Klinische Notfall- und Akutmedizin: Update - How to treat superficial thrombophlebitis?

This service is more advanced with Thrombophlebitis Blutungskomplikationen available, learn more at http: Über Jahre standen als therapeutische Optionen bei Varikose nur die offene Operation oder die Verödung mit flüssigen Mitteln zur Verfügung. In der letzten Dekade hat sich das therapeutische Spektrum durch die Einführung endovenöser Techniken wie Radiofrequenzobliteration und endovenöse Lasertherapie und die Renaissance der Verödung mit aufgeschäumten Agenzien deutlich erweitert.

Tritt im Rahmen einer Varikose oder einer Systemerkrankung eine Thrombophlebitis auf, reichen die therapeutischen Empfehlungen von elastokompressiven Verbänden über die operative Sanierung bis hin zur Thromboseprophylaxe und therapeutischen Antikoagulation, Thrombophlebitis Blutungskomplikationen.

Klassische und neue Therapieverfahren bei Varikose und Thrombophlebitis Venenerkrankungen. Original- und Übersichtsarbeiten Angiologie First Online: Rabe E, Pannier F. Sclerotherapy of varicose veins with Polidocanol based on the guidelines of the German Society of Phlebology Surg ; Neurological complications of sclerotherapy for varicose veins, Thrombophlebitis Blutungskomplikationen. J Vasc Surg Jan. Three-year European follow-up of endovenous radiofrequency-powered segmental thermal ablation of the great saphenous vein with or without treatment Thrombophlebitis Blutungskomplikationen calf varicosities.

Endovenous therapies of lower extremity varicosities: Endovenous thermal ablation of superficial venous insufficiency of the lower extremitiy: A six-year experience with endovenous laser in the treatment of Thrombophlebitis Blutungskomplikationen extremity varices, Thrombophlebitis Blutungskomplikationen. Rozhl Chir ; Christenson JT, Gueddi S, Gemayel G, Bounameaux H, Thrombophlebitis Blutungskomplikationen, Prospective randomized trial comparing endovenous laser ablation and sugery for treatment of primary grat saphenous varicose veins with a 2-year flow-up.

Epub Jan Strategien zur Antikoagulation und Operation bei akuter Thrombophlebitis. Zentralbl Chir ; Andreozzi GM, Verlato F. Minerva Cardioangiologica ; 48 Suppl 1: Superficial vein thrombophlebitis — serious concern or much ado about little Vasa ; Cite article How to cite?

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Thrombophlebitis Blutungskomplikationen

The contribution of dosing to the observed sex-related differences in bleeding is unknown. Major bleeding was adjusted for clinical factors and antithrombotic dose. Despite similar serum creatinine levels, Thrombophlebitis Blutungskomplikationen, creatinine clearance averaged 20 points lower among treated women than men.

Excess dosing was Thrombophlebitis Blutungskomplikationen with increased risk of bleeding in women OR 1. Received February 13, ; revision received June 14, ; accepted June 23, In fact, there are now more deaths annually due to cardiovascular disease among women than men. Relative to national averages, CRUSADE hospitals are larger and more likely to have catheterization laboratories and surgical capabilities.

Participating hospitals collect data through retrospective chart review using standardized data collection tools. Individual informed consent is not required because data are collected anonymously, without unique patient identifiers. The median 25th, 75th percentile number of patients from each participating hospital was 78 33, Creatine Thrombophlebitis Blutungskomplikationen was estimated with the Cockcroft-Gault formula, 20 using age, sex, Thrombophlebitis Blutungskomplikationen, Thrombophlebitis Blutungskomplikationen, and body weight.

In addition, excess heparin dose was considered in the adjustment as defined previously. To explore factors associated with excess dosing, we developed a model using generalized estimating equations that accounted for within-hospital clustering of responses, Thrombophlebitis Blutungskomplikationen, because patients at the same hospital are more likely to be similar to each other than to those at other hospitals.

Finally, we used a 3-level variable for dose excess dose or appropriate dose versus not treated for major bleeding model 3.

All analyses were performed with SAS software version 8. The authors had full access to the data and take full responsibility for their integrity. All authors have read and agree to the manuscript as written.

Compared with treated men, Thrombophlebitis Blutungskomplikationen, treated women were older, weighed less, Thrombophlebitis Blutungskomplikationen, and had more diabetes mellitus, hypertension, prior stroke, prior myocardial infarction, and prior CHF. In addition, treated women were equally likely to have positive cardiac markers, to receive heparin, and to undergo diagnostic catheterization during hospitalization but less likely to undergo percutaneous or surgical revascularization Table 1.

In addition, untreated patients were less likely to have ECG changes or positive cardiac markers and more likely to have signs of CHF at admission Table 1, Thrombophlebitis Blutungskomplikationen. Untreated patients were also less likely than treated patients to receive other antiplatelet and heparin therapies or to undergo cardiac catheterization or revascularization, Thrombophlebitis Blutungskomplikationen.

In addition, excess dosing was more common Thrombophlebitis Blutungskomplikationen women Women had a 4-fold higher unadjusted likelihood of receiving an excessive dose than men OR 4.

Older age OR 1. Major bleeding events occurred in Thrombophlebitis Blutungskomplikationen Among treated patients, major bleeding occurred more often in women than in men Among those not treated, major bleeding was also more common in women than in men 8. Major bleeding was higher in women than in men in subgroups receiving excess doses or appropriate doses and among those not treated Figure 2. Although the crude rates of major bleeding were only slightly higher in appropriately dosed men compared with those not treated, Thrombophlebitis Blutungskomplikationen, this difference was significant after adjustment for variables in major bleeding model 2a adjusted OR 1.

Men also had 3 times the rate of bleeding if given an excessive versus an appropriate dose, but after adjustment for variables in major bleeding model 2b, this was no longer significant adjusted OR 1. In women, the crude rates of major bleeding were higher in appropriately dosed patients than in those not treated, as well as in those given an excessive dose compared with an appropriate dose, and these differences remained significant after adjustment for variables in major bleeding model 2a adjusted OR 2.

Probability values represent unadjusted comparisons, Thrombophlebitis Blutungskomplikationen. When we considered the OR for bleeding with excess dose among men OR 1.

However, when we considered the OR for bleeding associated with excess dose among women OR 1. After adjustment for patient factors and excess dose, sex differences in bleeding remain. Although other treatment factors may also contribute to risk differences, the proportion of bleeding attributable to excess dosing in community practice is 5-fold higher among women than among men However, treated women were still at higher risk and were less likely to undergo revascularization than treated men.

Female sex has also been linked to bleeding risk in other clinical settings with a variety of antithrombotic agents ie, thrombolytics, unfractionated heparin, and low-molecular-weight heparin. Differences in platelet reactivity have also been suggested to exist in relation to levels of sex hormones, but these are speculative. Combinations of antithrombotic agents may pose more risk in women, or the dichotomous cutpoints used to Thrombophlebitis Blutungskomplikationen excess dose may not account for the continuous nature of the dose-response curve.

Pharmacological responses to therapeutic agents may also differ between the sexes. In practical terms, a year-old woman pounds with apparently normal serum creatinine of 1. The relationship between creatinine clearance and dose-related Thrombophlebitis Blutungskomplikationen may also be continuous, or other sex-related differences may alter the ideal thresholds for adjustment.

In conclusion, routine estimation of creatinine clearance and dose adjustment of narrow therapeutic index drugs during loading and infusion protocols must be prioritized. Even with appropriate adjustment, Thrombophlebitis Blutungskomplikationen, providers must remain vigilant for bleeding in women.

We describe only major bleeding as a complication; the inclusion of minor bleeding would likely increase the association between dosing and bleeding in women. In addition, other aspects of bleeding risk, such as history of bleeding diathesis, concomitant use of drugs that affect coagulation eg, Thrombophlebitis Blutungskomplikationen, nonsteroidal anti-inflammatory drugs or warfarinThrombophlebitis Blutungskomplikationen, and specific timing in relation to procedures and duration of therapy were not assessed.

Dose adjustments made after the initial dose were not considered. Finally, consecutive patient enrollment in CRUSADE is requested but not monitored, and data elements are not adjudicated by source documents. Interval assessments of chart abstraction have demonstrated a high level of correlation between the case report form and actual care, Thrombophlebitis Blutungskomplikationen. We appreciate Thrombophlebitis Blutungskomplikationen excellent editorial support of David Bynum.

The remaining authors report no conflicts. Women represent a large proportion of patients treated for non—ST-segment elevation acute coronary syndromes and are known to experience more bleeding than men in the course of routine care. Excess dosing was associated with increased risk of bleeding in women and men alike, and women had higher rates of major bleeding than men if treated Most important, Thrombophlebitis Blutungskomplikationen, the risk attributable to dosing excess was Thrombophlebitis Blutungskomplikationen higher in women Therefore, variations in dosing among high-risk subgroups may be sufficient to alter the risk profile of therapeutics and limit benefits.

We only request your email Ich bin 25 und ich habe Krampfadern so that the person you are recommending the page to knows that you wanted them to see it, Thrombophlebitis Blutungskomplikationen, and that it is not junk mail. We do not capture any email address. Skip to main content. AlexanderAnita Y. Kristin NewbyJanice B.

SchwartzRita F. RedbergJudith S. HochmanMatthew T. Brian GiblerE. Magnus OhmanEric D. Results Women constituted View inline View popup. Major Bleeding by Sex and Treatment Major bleeding events occurred in Major Bleeding by Sex and Excess Dosing Major bleeding was higher in women than in men in subgroups receiving excess doses or appropriate doses and among those not treated Figure 2. Women and Cardiovascular Diseases: American Heart Association; Gender disparities in the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: J Am Coll Cardiol.

A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. N Engl J Med, Thrombophlebitis Blutungskomplikationen. Receptor Suppression Using Integrilin Therapy. Influence of clinical trial enrollment on the quality of Thrombophlebitis Blutungskomplikationen and outcomes for patients with non-ST-segment elevation acute coronary syndromes.

Excess dosing of anti-platelet and anti-thrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes. Improving the care of patients with non-ST-elevation acute coronary syndromes in the emergency department: American College of Cardiology key data elements and definitions Thrombophlebitis Blutungskomplikationen measuring the clinical management and outcomes of patients with acute coronary syndromes: Integrilin Thrombophlebitis Blutungskomplikationen [package insert], Thrombophlebitis Blutungskomplikationen.

South San Francisco, Calif: Millennium Pharmaceuticals, Inc; Heparin dosing and outcome in acute coronary syndromes: Safety and efficacy of unfractionated heparin versus enoxaparin in patients who are obese and patients with severe renal Thrombophlebitis Blutungskomplikationen Prediction of creatinine clearance from serum creatinine.

Liang K, Zeger S. Longitudinal data analysis using generalized linear models, Thrombophlebitis Blutungskomplikationen. Predictors of major bleeding Folgen von Thrombophlebitis acute coronary syndromes: Principles and Quantitative Methods. Lifetime Learning Pub; Sex and racial differences in the management Thrombophlebitis Blutungskomplikationen acute myocardial infarction, through Thrombophlebitis Blutungskomplikationen coronary intervention and adjunctive pharmacotherapy in women: Bleeding events with abciximab Thrombophlebitis Blutungskomplikationen acute coronary syndromes without early revascularization: Walker AM, Jick H.

Predictors of bleeding during heparin therapy. Incidence and predictors of bleeding after contemporary thrombolytic therapy for myocardial infarction. Predictors of bleeding complications after rescue coronary interventions.


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